Organic Syntheses, Coll. Vol. 2, p.341 (1943); Vol. 14, p.48 (1934).
Sixty grams (0.43 mole) of potassium carbonate (Note 1)
is slowly stirred into a mixture of 100 g. (0.725 mole) of u.s.p. salicylic acid
and 150 cc. of water contained in a 20-cm. porcelain dish
. The solution is evaporated on a steam bath
until a thick, pasty residue is obtained. This is broken up into small pieces and dried in an oven at 105–110° for two hours. The solid is then ground as finely as possible, dried for another two hours at 105–110°, and again ground to a fine powder.
The finely powdered mixture of potassium salicylate
is placed in a 500-cc. round-bottomed flask
which is immersed in an oil bath
so that only a small portion of the neck protrudes from the bath (Note 2)
. The bath is heated to 240° (Note 3)
and maintained at this temperature for one and one-half hours. During this time the solid in the flask is stirred occasionally with a curved glass rod flattened at the end.
When the reaction is completed (Note 4)
, the product is transferred as completely as possible, while hot, to a 2-l. flask containing 1 l. of hot water
. The reaction flask is rinsed with several portions of the hot solution. The alkaline solution is acidified with concentrated hydrochloric acid (about 75 cc. is required)
, heated nearly to boiling, treated with 5–6 g. of decolorizing charcoal, and filtered to remove a small quantity of brown resin. The filtrate is cooled under the tap, and the crude brown crystalline product is filtered with suction. The filtrate is concentrated to a volume of approximately 300 cc. and cooled as before. The second crop of crude acid is filtered with suction and combined with the main portion. The total weight of crude p-hydroxybenzoic acid
, m.p. 208–211°
, is 40–45 g.
The crude acid is dissolved in 300 cc. of hot water, boiled with 4–5 g. of decolorizing charcoal for a few minutes, and the solution filtered. After cooling thoroughly under the tap the purified product is filtered with suction and washed with 10–15 cc. of cold water. The purified acid weighs 35–40 g. (70–80 per cent of the theoretical amount) and melts at 211–212°.
An excess of potassium carbonate
is used since it prevents the mass from caking during the subsequent heating. Although the original mixture is strongly alkaline a clear solution may not be obtained until the dish is heated.
In this way the phenol
formed in the reaction is allowed to distil out of the mixture. This operation should be carried out in a hood.
The temperature reported is that of the oil bath; the internal temperature is approximately 230°. The temperature should be controlled carefully since pronounced decomposition sets in at higher temperatures.
The completeness of the reaction may be determined roughly by treating a small test portion with 3–4 cc. of hot water and acidifying with concentrated hydrochloric acid
. Since p-hydroxybenzoic acid
is relatively soluble and salicylic acid
only sparingly so, the absence of a precipitate in the warm solution indicates that the reaction is essentially complete.
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