Organic Syntheses, Coll. Vol. 2, p.384 (1943); Vol. 14, p.58 (1934).
) Ethyl Sodium Phthalimidomalonate
.—To a solution of 9.2 g. (0.4 gram atom) of sodium in 300 cc. of absolute alcohol
at 60° is added, with efficient stirring, 126 g. (0.41 mole) of ethyl phthalimidomalonate (Org. Syn. Coll. Vol. I, 1941, 271)
. The mixture is rapidly chilled to 0°; the crystalline product is filtered at once by suction and washed successively with two 200-cc. portions of absolute alcohol
and two 200-cc. portions of ether
. After first drying in a vacuum desiccator
and then heating for eight hours under 15 mm. pressure in a flask suspended in an oil bath
at 145–155° (Note 1)
, the product weighs 108–111 g.
per cent of the theoretical amount).
) Ethyl 1-Methylthiol-3-phthalimidopropane-3,3-dicarboxylate
.—A mixture of 85 g. (0.26 mole) of ethyl sodium phthalimidomalonate
and 43 g. (0.39 mole) of β-chloroethyl methyl sulfide (p. 136)
is heated in an oil bath at 160–165° in a 1-l. three-necked flask
, fitted with a condenser
, a thermometer
, and a stoppered glass tube
for sampling. After one and a half to two hours the mixture is no longer alkaline to litmus. The excess chloroethyl methyl sulfide
is distilled under reduced pressure (Note 2)
, the residual oil is treated with 150 cc. of warm water, and the resulting mixture is transferred to a beaker
and chilled. The crystalline material is filtered by suction, washed with 100 cc. of cold water, and recrystallized from the smallest possible quantity of warm absolute alcohol
. In this way 75–79 g.
per cent of the theoretical amount) of a pure product, melting at 66–67°
, is obtained.
) 1-Methylthiol-3-phthalamidopropane-3,3-dicarboxylic Acid
.—A solution of 25 g. (0.066 mole) of the above ester in 30 cc. of 95 per cent alcohol
is heated on the steam bath
in a 200-cc. round-bottomed flask
, and 70 cc. of 5N sodium hydroxide
is added. The cloudy liquid is heated until a sample gives a clear solution on dilution with water; this occurs after about two hours. The solution is then chilled to 0° and cautiously neutralized to Congo red with 0.2 N hydrochloric acid, whereupon 75 cc. of 5 N hydrochloric acid
is slowly added, the temperature being maintained at 0°. The acid separates as colorless crystals. This separation is completed by the slow addition of 60 cc. of concentrated hydrochloric acid
(sp. gr. 1.19). The product is filtered by suction and washed free of salt with small quantities of ice-cold water. After drying in vacuo
, the yield is 21.5–22 g.
per cent of the theoretical amount) of a product melting at 141–143°
.—A suspension of 21.5 g. (0.063 mole) of this tricarboxylic acid
in 350 cc. of hot water is heated on the steam bath, and 40 cc. of concentrated hydrochloric acid
(sp. gr. 1.19) is added. Carbon dioxide
is immediately evolved, and the substance goes into solution. After heating for one and a half hours, 200 cc. more of concentrated hydrochloric acid
is added and heating is continued for forty-five minutes longer. The solution, on cooling, deposits phthalic acid
; this is filtered and washed with two 50-cc. portions of water (Note 3)
. The combined filtrate and washings are evaporated to dryness on the steam bath under reduced pressure, and the dry residue is dissolved in 50 cc. of hot water. The resulting solution is treated with 18 cc. of pyridine
and poured into 150 cc. of hot absolute alcohol
rapidly crystallizes; after cooling it is filtered, washed with alcohol, and dried. The first crop weighs about 6.9 g.
The mother liquor is evaporated to dryness; the residue is taken up in 15 cc. of hot water and poured into 50 cc. of absolute alcohol
, when a further 1.3 g.
is obtained. The total 8.2 g.
of nearly pure methionine
is suspended in 200 cc. of boiling absolute ether
, filtered, and dried. In this way, 7.9–8.0 g.
per cent of the theoretical amount), melting at 279–280°
(corr.), is obtained.
About 10–12 g. of a pure product can be recovered by redistilling the distillate.
The first synthesis of methionine
, by the Strecker method, gave a very low yield.1
The procedure given above, based on directions published by the submitters,2
has the advantage over the process of Windus and Marvel3
of giving a much higher yield (54–60
per cent as against 13–19
per cent, based on the β-chloroethyl methyl sulfide
This preparation is referenced from:
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