Organic Syntheses, Coll. Vol. 1, p.537 (1941); Vol. 6, p.96 (1926).
To a cold solution of 80 g. (2 moles) of sodium hydroxide
in 500 cc. of water in a 1-l. flask
is added 50 g. (0.266 mole) of gallic acid
. The flask is immediately tightly stoppered (Note 1)
, and the mixture shaken occasionally until all the acid has dissolved; 89 g. (67 cc.) of dimethyl sulfate (0.71 mole)
is then added (Note 2)
and the flask is shaken for twenty minutes, being cooled by means of cold water in order that the temperature does not rise above 30–35°. Occasionally the stopper is raised to release any pressure. A second portion of 89 g. of dimethyl sulfate
is then added and shaking continued for ten minutes longer. During this second addition the temperature may rise to 40–45°.
The flask is then fitted with a reflux condenser
and the contents boiled for two hours. In order to saponify the small amount of ester which is produced, a solution of 20 g. of sodium hydroxide
in 30 cc. of water is then added and boiling continued for two additional hours. The reaction mixture is then cooled and acidified with dilute hydrochloric acid
; the precipitated trimethylgallic acid
is filtered with suction and washed well with cold water. The product, which melts at 157–160°
, is sufficiently pure for many purposes. It weighs 50–52 g.
per cent of the theoretical amount). It may be purified by recrystallization from 2 l. of boiling water with the use of decolorizing carbon
, the filtration being carried out in a steam-jacketed funnel
. In this way 41–43 g. (Note 3)
of colorless needles melting at 167°
The alkaline solution immediately darkens somewhat, owing to the presence of dissolved air; further oxidation must be limited by preventing access of air to the mixture. This is particularly necessary during the early stages; with increasing methylation the tendency to absorb oxygen
falls off rapidly. Sodium bisulfite
has been recommended to prevent oxidation during methylation.1
Access of air may be prevented in an apparatus that permits of mechanical stirring. For this purpose a three-necked flask
is provided with a mechanical stirrer
, separatory funnel
, and Bunsen valve
. The valve is made by cutting a vertical slit in a piece of rubber tubing, closed at one end by a solid glass plug or pinchcock
and attached at the other end to a piece of glass tubing contained in a stopper. Such a valve acts in one direction, permitting release of gas pressure. A guard tube filled with sodium hyposulfite
has been used to exclude oxygen
The toxic nature of methyl sulfate
must always be borne in mind. Ammonia
is a specific antidote for methyl sulfate
and should be kept at hand to destroy any of the ester accidentally spilled.
A further quantity can be recovered by concentrating the mother liquor. The residue of decolorizing carbon
is also likely to contain an appreciable proportion of trimethylgallic acid
, which can be extracted by boiling it with the mother liquor.
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