Organic Syntheses, Coll. Vol. 2, p.93 (1943); Vol. 11, p.20 (1931).
A solution of 200 g. (3.6 moles) of potassium hydroxide
in 200 cc. of water is placed in a 2-l. flask
fitted with a reflux condenser
. The mixture is heated to about 80°, and 202 g. (1 mole) of isopropylmalonic ester (Note 1)
is added through the condenser over a period of about one hour. The mixture should be shaken well to prevent the formation of two layers. The saponification proceeds rapidly, forming a clear solution. The solution is transferred to a 20-cm. evaporating dish
, the flask is rinsed with 50 cc. of water, and the solution and washings are evaporated practically to dryness on a steam bath (Note 2)
The residue is dissolved in 200 cc. of water, transferred to a 1-l. flask
, and cooled to 0° in an ice-salt bath
. A mixture of 400 cc. of concentrated hydrochloric acid
(sp. gr. 1.19) and 200 g. of cracked ice is added slowly until the mixture is acid to Congo red
. The temperature of the mixture must not rise above 10° (Note 3)
. Potassium chloride
separates. The mixture is extracted with two 200-cc. portions and four 100-cc. portions of alcohol-free ether (Note 4)
to remove the isopropylmalonic acid
. The ether
solution (Note 5)
is placed in a flask fitted with a reflux condenser, and 160 g. (1 mole) of bromine
is added gradually over a period of about two hours at such a rate that the ether
boils gently (Note 6)
. When the bromination is complete, the ether
solution is washed with 100 cc. of water to remove the hydrobromic acid
, dried over 25 g. of calcium chloride
, and freed from ether
by distillation on the steam bath. The crude isopropylbromomalonic acid
is heated in the distilling flask in an oil bath
at 125–130° until no more carbon dioxide
is evolved. It is then distilled under reduced pressure; the fraction distilling at 140–160°/40 mm. is collected separately and redistilled (Note 7)
. The yield of product boiling at 148–153°/40 mm.
) is 100–120 g.
per cent of the theoretical amount) (Note 8)
The isopropylmalonic ester
was prepared by the method used for n-butylmalonic ester (Org. Syn. Coll. Vol. I, 1941, 250)
. The yield of product boiling at 132–135°/44 mm.
per cent of the theoretical amount.
Unless the saponification is complete, the final product will contain ethyl α-bromoisovalerate
, which will appear in the low-boiling fraction. If all the alcohol is not removed, some esterification will occur on acidification.
used for extraction is first extracted with one-tenth its volume of saturated calcium chloride
solution to remove the alcohol, which would otherwise cause partial esterification of the acid.
No special drying is necessary before the bromination, but the ether
and aqueous layers should be separated carefully.
Usually the bromination starts easily. Sometimes, however, the mixture has to be heated after the first few drops of bromine
are added. The mixture may have to be heated to complete the bromination.
The product on the first distillation does not have a constant boiling point, as some carbon dioxide
is liberated from undecomposed isopropylbromomalonic acid
. This cannot be avoided by preliminary heating, even at temperatures much higher than those used.
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