Organic Syntheses, Coll. Vol. 2, p.221 (1943); Vol. 15, p.22 (1935).
A wide-mouthed 250-cc. flask (Note 1)
containing a mixture of 50 g. (0.25 mole) of technical 2,4-dinitrochlorobenzene (Note 2)
and 18 g. (0.23 mole) of ammonium acetate
is half immersed in an oil bath
. The flask is fitted with a reflux condenser
and an inlet tube, the lower end of which is at least 2 cm. wide
(to prevent clogging) and which nearly touches the surface of the reaction mixture. During the operation ammonia
gas is introduced through a bubble counter which contains a small amount of strong potassium hydroxide solution (12 g. of potassium hydroxide in 10 cc. of water)
The oil bath is heated to 170° and maintained at that temperature for six hours during which time ammonia
gas is passed through at the rate of three to four bubbles per second. After the mixture has cooled, the solid is broken up by means of a glass rod
and mixed with 100 cc. of water; the mixture is then heated to boiling and filtered while hot. The residue is dissolved in 500 cc. of boiling alcohol
, and water is added (about 150 cc.) until the solution becomes turbid. Heat is applied until the turbidity disappears and then the solution is allowed to cool. After standing overnight, the crystals are filtered and dried. The yield is 31–35 g.
per cent of the theoretical amount) of 2,4-dinitroaniline
, melting at 175–177° (Note 3)
and (Note 4)
. For further purification the product is recrystallized in the same manner from alcohol and water, using 20 cc. of alcohol
per gram of solid. Ninety
per cent of the crude material is recovered as recrystallized product melting sharply at 180°
The neck of the flask must be large enough to admit the wide inlet tube. A 250-cc. extraction flask is most convenient.
The technical dinitrochlorobenzene
used had a freezing point of 45°. The higher yield given is obtained using a product once recrystallized from alcohol (m.p. 48°
Some specimens of technical dinitrochlorobenzene
used contained undetermined impurities that formed double compounds with the dinitroaniline
. These remained in the filtrate. It was not worth the trouble to recover the small amount of amine thus lost.
The value of this method is that no autoclave is required. It was not satisfactory when applied to the nitrochlorobenzenes.
Chemical Abstracts Nomenclature (Collective Index Number);
sulfuric acid (7664-93-9)
ammonium acetate (631-61-8)
potassium hydroxide (1310-58-3)
Aniline, 2,4-dinitro- (97-02-9)
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