Organic Syntheses, Coll. Vol. 2, p.501 (1943); Vol. 19, p.70 (1939).
In a 1-l. three-necked, round-bottomed flask
, fitted with a liquid-sealed mechanical stirrer
and reflux condenser
, are placed 69 g. (0.5 mole) of o-nitroaniline (Org. Syn. Coll. Vol. I, 1941, 388)
, 40 cc. of a 20 per cent solution of sodium hydroxide
, and 200 cc. of 95 per cent ethanol
. The mixture is stirred vigorously and heated on a steam bath
until the solution boils gently. The steam is turned off, and 10-g. portions of 130 g. (2 gram atoms) of zinc dust (Note 1)
are added frequently enough to keep the solution boiling (Note 2)
and (Note 3)
. After the addition of zinc
dust has been completed the mixture is refluxed with continued stirring for one hour; the color of the solution changes from a deep red to nearly colorless. The hot mixture is filtered by suction, and the zinc
residue is returned to the flask and extracted with two 150-cc. portions of hot alcohol
. To the combined filtrates is added 2–3 g. of sodium hydrosulfite
, and the solution is concentrated under reduced pressure (using a water pump
), on a steam bath, to a volume of 125–150 cc. After cooling thoroughly in an ice-salt bath
, the faintly yellow crystals are collected, washed once with a small amount of ice water, and dried in a vacuum desiccator
. The yield of crude o-phenylenediamine
melting at 97–100°
is 46–50 g.
per cent of the theoretical amount). If a purer product is desired, the material is dissolved in 150–175 cc. of hot water containing 1–2 g. of sodium hydrosulfite
and treated with decolorizing charcoal. After cooling thoroughly in an ice-salt mixture, the colorless crystals are filtered by suction and washed with 10–15 cc. of ice water. The purified o-phenylenediamine
weighs 40–46 g.
per cent of the theoretical amount) and melts at 99–101° (Note 4)
and (Note 5)
The zinc dust should be at least 80 per cent
pure, and the amount used should be equivalent to 130 g. of 100 per cent material. A large excess of zinc
dust has been used without changing the yield.
Great care must be taken not to add too much zinc
dust at first as the reaction becomes very vigorous. It is well to have a bath of ice and wet towels at hand in order to control the reaction if it should become too violent.
Occasionally the reaction suddenly stops and it is necessary to add an additional 10 cc. of 20 per cent sodium hydroxide
solution, which causes the reaction to proceed.
The product can also be purified by distillation under reduced pressure in an inert atmosphere, but, unless the material is very nearly pure, considerable decomposition occurs and the distilled product darkens rapidly in contact with air.
The free diamine may also be converted into the dihydrochloride, and the salt purified as follows: The crude o-phenylenediamine
is dissolved in a mixture of 90–100 cc. of concentrated hydrochloric acid
(sp. gr. 1.19) and 50–60 cc. of water containing 2–3 g. of stannous chloride
, and the hot solution is treated with decolorizing charcoal. To the hot, colorless filtrate is added 150 cc. of concentrated hydrochloric acid
, and the mixture is cooled thoroughly in an ice-salt bath. The colorless crystals are filtered by suction, washed with a small amount of cold concentrated hydrochloric acid
, and dried in vacuum over solid sodium hydroxide
. The yield of o-phenylenediamine dihydrochloride
is 77–81 g.
per cent of the theoretical amount based on the weight of o-nitroaniline
has been proposed as a reagent for the identification of aliphatic acids, by conversion to crystalline 2-alkylbenzimidazoles (p. 65)
This preparation is referenced from:
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