Organic Syntheses, Coll. Vol. 3, p.332 (1955); Vol. 25, p.35 (1945).
In a 2-l. round-bottomed flask
provided with a reflux condenser
is placed 200 ml. of dry benzene (Note 1)
. A mixture of 300 g. (5.08 moles) of finely divided acetamide
and 200 g. (0.9 mole) of powdered phosphorus pentasulfide
is prepared quickly and transferred immediately to the flask. To this is added 20 ml. of a mixture of 400 ml. (4.97 moles) of chloroacetone (Note 2)
and 150 ml. of dry benzene
. The exothermic reaction is started by careful heating in a water bath
. The water bath is removed, and the remainder of the chloroacetonebenzene
mixture is introduced gradually through the reflux condenser (Note 3)
and (Note 4)
. When all the chloroacetone
has been added and reaction is no longer apparent, the mixture is refluxed on the water bath for 30 minutes.
About 750 ml. of water is added to the mixture with shaking. After 30 minutes the mixture is poured into a separatory funnel
, and the reddish upper layer containing the benzene
with some impurities is discarded. The lower layer is made alkaline (Note 5)
by the addition of 5 N sodium hydroxide
or potassium hydroxide
, and the crude thiazole
, which separates as a black upper layer, is removed with ether
, and the aqueous lower layer is extracted with five 120-ml. portions of ether
. The combined ethereal extracts are dried over anhydrous sodium sulfate
and filtered through glass wool. The ether
is removed by distillation from a steam bath (Note 6)
, and the residual oil is fractionated at atmospheric pressure; the fraction boiling at 140–150°
is collected and redistilled. The yield of 2,4-dimethylthiazole
boiling at 143–145° (Note 7)
is 210–230 g.
based on the phosphorus pentasulfide
is distilled, and the fraction boiling at 116–122°
The progress of the reaction is controlled by the portions of chloroacetone
added. If too much is added at once the reaction may become too vigorous. Portions of 20 ml. are safe. Toward the end of the reaction, larger portions may be added.
As soon as the reaction has begun, the mixture becomes a gray-black oily liquid.
The alkalinity of the deeply colored solution can be tested with phenolphthalein
paper. The edges of the wetted paper become visibly red. One should be sure to test the aqueous solution and not the separated thiazole
floating on top of the liquid.
is hygroscopic and should be protected from moisture.
Reported boiling points are 144–145.5°/719 mm.1
(b.p. 108°) was obtained during the distillation.
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