Organic Syntheses, Coll. Vol. 4, p.5 (1963); Vol. 33, p.1 (1953).
A commercial C.P.
grade can be used. The checkers used Merck A.R. grade.
A commercial grade, 95% minimum assay, can be used. The checkers used Merck A.R. grade.
Any good commercial grade material appears to be satisfactory.
Reducing the molar ratio of pyridine
or anhydride to the amino acid reduces the yield.
Without stirring the yield is 46%.
With other amino acids, notably glycine
, it is necessary to reflux the reactants 1–6 hours.
The checkers found it necessary to heat the column to obtain the maximum available product.
This preparation is referenced from:
Copyright © 1921-, Organic Syntheses, Inc. All Rights Reserved