Org. Synth. 1925, 4, 39
Submitted by C. D. Hurd
Checked by Oliver Kamm
(A) Preparation of Ketene.—The arrangement of the apparatus is shown in Fig. 19 (Note 1). The graduated separatory funnel, shown in the diagram, filled with 100 g. (126 cc., 1.7 moles) of commercial acetone, leads into a 500-cc. round-bottomed flask which, in turn, is connected by gas-tight joints (Note 2) to a glass combustion tube filled with broken porcelain, a spiral or bulb condenser, a three-way stopcock, and a reaction flask. In the reaction flask is placed the material with which the ketene is to react (Note 3). A second reaction flask may be placed in series, if desired, to ascertain if any ketene escaped reaction in the first flask.
Prior to either of these steps, fourteen of the twenty burners of the combustion furnace are lighted (Note 4) and tiles are placed over the lighted burners, which finally must be adjusted to yield a maximum temperature. The first two and last four burners are unused.
When the furnace is fully heated, boiling water is placed beneath the round-bottomed flask and cold water passed through the condenser. Acetone is now dropped in at the rate of 3–4 cc. per minute. About one-half the acetone should be recovered as distillate in cylinder B (Note 5). Ketene, admixed with methane, carbon monoxide, and ethylene, passes into the reaction flasks (Note 6) in 25–29 per cent yields of the theoretical amount. The flow may be interrupted at will by checking the acetone flow (Note 7).
(B) Preparation of Acetanilide.—Since ketene is a highly reactive gas, it is usually prepared for immediate consumption instead of being isolated as such. It reacts with various groups which contain hydrogen, such as hydroxyl, amino, mercaptan, hydroxylamino, etc., forming acetyl derivatives.
Twenty-five grams (0.27 mole) of aniline is placed in the reaction flask, D, and 50 cc. of dry ether added as solvent (Note 8). A second reaction flask is connected at C, in which is placed 5 g. of aniline, dissolved in 20 cc. of dry ether. This prevents the escape of ketene vapor at the beginning and at the close of the operation (Note 5). In all, 85 cc. of acetone is passed through the apparatus, 39 cc. of which is recovered as distillate. Therefore, 44 cc. (or 35 g.) of acetone is decomposed. The duration of the run is about thirty minutes. Twenty-one grams of acetanilide, which corresponds to a yield of 25.8 per cent of the theoretical amount, based upon the amount of acetone decomposed, is isolated from the reaction mixture (Note 9).
. A graduated dropping funnel
and a graduated cylinder
for the distillate are chosen because of convenience in determining the volume of decomposed acetone
The bulb (or spiral) condenser is chosen because of its efficiency. With an ordinary condenser, it is necessary to insert two U-tubes, cooled by ice, between the condenser and the reaction flask, to remove all the acetone from the ketene. In many reactions, however, this admixed acetone will do no harm. This part of the apparatus is designed to eliminate the loss of ketene by solvent action, prior to its entry into the reaction flask.
A wide-mouthed delivery tube in the reaction flask is essential to prevent clogging, when a solid product is formed. Automatic stirring in the reaction flask may be used to advantage in certain instances. There is constant agitation, of course, as the gaseous decomposition products bubble through.
Either Scotland glass or Pyrex is satisfactory for the combustion tube. An estimate of the temperature is 650° (Note 4). The life of the tube is lengthened if it rests upon a layer of thin asbestos paper. The tube is filled with pieces of broken porcelain, to serve as a "heat reservoir"; there is no catalytic effect. The porcelain blackens during the reaction.
Care in Assembly
.—Since this is a gaseous reaction, it is essential that the apparatus be free from leaks; thus, corks
are eliminated whereever possible. The ends of the combustion tube and the top of the condenser are drawn to the diameter of the connecting tubes
and joined by a piece of thick-walled rubber tubing
. Care should be taken to have the ends of the glass tubes come into contact. The rubber tube
situated between the furnace and condenser is protected by the asbestos screen, but a further essential precaution is taken, namely, that this end of the combustion tube extend a considerable distance from the furnace.
The stoppers in the reaction flask and at the top of the dropping funnel are of rubber; the other two are well-selected corks, bored perfectly and painted both inside and out with water-glass, one day previous to being used.
The apparatus may be calibrated by allowing the ketene
to react with 5 N
alkali and titrating the excess alkali with acid.
With an electric combustion furnace
, wherein a temperature of 695–705°
is maintained, consistent yields of 35–40
per cent ketene
are produced. The best rate of flow in such a case is 4–6 cc. per minute, with recovery of 60–80 per cent of the original acetone
as distillate. Although yields of ketene
ranging above 45
per cent have been obtained frequently with this apparatus, they could not be duplicated consistently.
The thermal decomposition of ketene
into carbon monoxide
is prevented, as far as possible, by the rapid removal of ketene
from the hot tube, which is accomplished by the undecomposed acetone
vapor. About half the acetone
originally used should be collected unchanged as distillate by the vertical condenser
. The yield of ketene
will fall considerably if less distillate is formed.
gas is very irritant when inhaled, and hence proper cautions should be taken to avoid inhalation.
The generator, Fig. 19, is easily assembled from apparatus which can be found in almost every laboratory. Offsetting these advantages is the low yield of ketene
obtained. If the necessary equipment is available, the generator described by Williams and Hurd1
is recommended in place of the one shown above. With the Williams and Hurd generator
, the yield of ketene
per cent based on the acetone
decomposed, and the output is 0.45 mole of ketene
per hour. The generator may be run intermittently, or continuously for a period of twenty-four hours, and requires a minimum of attention (Jonathan L. Williams and Charles D. Hurd, private communication checked by N. L. Drake).
An ice bath
surrounding the reaction flask is usually employed not only to prevent the vaporization of the solvent, but also to promote a greater solubility of ketene
It has been found that the formation of acetanilide from ketene and aniline takes place more satisfactorily if the ketene is passed directly into excess aniline without any dry ether present. The excess aniline may then be removed by distillation under reduced pressure until the temperature of the vapors is 10–15° higher than the boiling point of aniline. An alternative plan is to remove excess aniline by dilute hydrochloric acid, to filter the acetanilide, and to wash with water.
It is suggested that improved yields of ketene
may be obtained by directly dropping the acetone in at a rate of about 2 cc.
per second instead of slowly distilling it into the hot tube (C. D. Hurd, private communication).
can be prepared by the pyrogenic decomposition of acetic anhydride
and other ketones;5
and by the action of zinc on an ethereal solution of bromoacetyl bromide
The procedure described is based on work of Schmidlin and Bergmann4
as modified by Hurd and Cochran.4
The preparation of ketene
has been the subject of numerous articles and patents.7
The more recent work usually involves either the use of hot metallic filaments or of metallic oxide catalysts.8
This preparation is referenced from:
Chemical Abstracts Nomenclature (Collective Index Number);
hydrochloric acid (7647-01-0)
acetic anhydride (108-24-7)
carbon monoxide (630-08-0)
bromoacetyl bromide (598-21-0)
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