Org. Synth. 1939, 19, 18
[Caproic acid, ε-benzamido-α-bromo-]
Submitted by J. C. Eck and C. S. Marvel.
Checked by C. R. Noller and William Munich.
An intimate mixture of 150 g. (0.64 mole) of dry ε-benzoylaminocaproic acid (p. 76)
and 26.4 g. (0.85 gram atom) of dry red phosphorus
is placed in a 1-l. three-necked flask
provided with a separatory funnel
, an air-cooled condenser
connected through a calcium chloride tube
to a water trap
, and a mechanical stirrer (Note 1)
. The reaction flask is surrounded by an ice-salt mixture, the stirrer started, and 408 g. (131 cc., 2.55 moles) of dry bromine
added dropwise from the separatory funnel. When all the bromine
has been added the cooling bath
is removed. The mixture is warmed slowly at first and finally heated on a steam bath
, with stirring, until the bromine
vapors have practically disappeared. The hot mixture is poured slowly into 400 cc. of water in a 1-l. beaker
with hand stirring. The viscous acid bromide reacts with the water with the evolution of heat, and the solid acid is formed. The lumps are pulverized, the mixture is replaced in the original reaction flask, and the whole is treated with a slow stream of sulfur dioxide
to remove excess bromine
. The solid product is filtered on a Büchner funnel
, washed with three 50-cc. portions of water, and air-dried. The crude material is dissolved in 250 cc. of hot 95 per cent alcohol
, filtered, and poured with stirring into 1 l. of cold water (Note 2)
. After filtering and air-drying, 130–180 g.
per cent of the calculated amount) of acid
melting at 162–165°
The stirrer must be very powerful because the mixture becomes lumpy and finally very viscous. If the material agglomerates so badly that the stirrer will not operate, hand stirring may be necessary temporarily until the mass liquefies sufficiently to renew mechanical stirring. The checkers tried one run in which carbon tetrachloride
was added to facilitate stirring, but, though it accomplished this purpose, the yield was only about half of that obtained without a liquid medium.
The crude product may be recrystallized from ethyl alcohol
, but the melting point is the same as that of the product obtained by precipitation with water, and the yield is considerably less.
The above procedure1
is essentially that of Braun.2
This preparation is referenced from:
Chemical Abstracts Nomenclature (Collective Index Number);
sulfur dioxide (7446-09-5)
carbon tetrachloride (56-23-5)
Caproic acid, ε-benzamido-α-bromo- (1700-05-6)
ε-Benzoylaminocaproic acid (956-09-2)
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