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Org. Synth. 1936, 16, 71
DOI: 10.15227/orgsyn.016.0071
PHTHALIDE
Submitted by J. H. Gardner and C. A. Naylor Jr.
Checked by H. T. Clarke and D. Blumenthal.
1. Procedure
In a 2-l. round-bottomed flask, 180 g. (2.75 gram atoms) of zinc dust is stirred to a thick paste with a solution of 1 g. of copper sulfate in about 35 cc. of water (Note 1), and 400 g. (327 cc.) of 20 per cent aqueous sodium hydroxide is added. The flask is equipped with a mechanical stirrer, the contents are cooled to 5° by means of an ice bath, and 147 g. (1 mole) of phthalimide (Org. Syn. Coll. Vol. I, 1941, 457) is added in small portions at such a rate that the temperature does not rise above 8° (about thirty minutes is required). After all the phthalimide has been added, stirring is continued for one-half hour. The mixture is diluted with 400 cc. of water, warmed on a steam bath until evolution of ammonia has ceased (about three hours), and concentrated to a volume of about 400 cc. by distillation under reduced pressure. The material is filtered and the filtrate made acid to Congo red with concentrated hydrochloric acid (about 150 cc. is required). The mixture, in which the phthalide has separated as an oil, is boiled for one hour in order to complete the lactonization of the hydroxymethylbenzoic acid, and transferred while hot to a beaker. On cooling, the oily product solidifies to a hard red-brown cake. After chilling overnight in a refrigerator, when a further quantity of crystalline solid separates from the aqueous layer, the cold mixture is filtered with suction (Note 2). The crude phthalide, which contains a considerable quantity of sodium chloride, is recrystallized in 20-g. portions from 1.5 l. of water; the mother liquor from the first crop is employed for recrystallization of the subsequent portions. Each portion is filtered hot and cooled below 5° before collecting the crystals, which are finally washed with small quantities of ice-cold water (Note 3). The phthalide crystallizes in transparent plates which melt at 72–73°. The yield is 90–95 g. (67–71 per cent of the theoretical amount) (Note 4).
2. Notes
1. In checking these directions complete failure was repeatedly encountered with good commercial grades of zinc dust, and only when the metal was activated with copper sulfate did reduction proceed at all.
2. The mother liquor, on concentrating to less than half its volume, yields no further crystals on chilling.
3. On cooling, a minute amount of a yellow impurity separates with the phthalide at the beginning of crystallization. This impurity apparently cannot be eliminated by boiling with charcoal but is present in too small amount to affect the melting point of the product.
4. Concentration of the final mother liquor to a volume of 500 cc. yields a further small quantity of phthalide, but this operation is scarcely worth while.
3. Discussion
Phthalide has been prepared by the bromination of o-toluic acid followed by hydrolysis;1 by the reduction of phthalic anhydride,2 ammonium phthalate,3 or ethyl acid phthalate;4 and by the method described in the procedure above.5

References and Notes
  1. Hjelt, Ber. 19, 412 (1886); Salkind and Ssemenow, J. Russ. Phys.-Chem. Soc. 46, 512 (1914) (Chem. Zentr. 1914, II, 1271); Davies and Perkin, J. Chem. Soc. 121, 2207 (1922).
  2. Wislicenus, Ber. 17, 2181 (1884); Godchot, Bull. soc. chim. (4) 1, 830 (1907); Sabatier and Kubota, Compt. rend. 172, 736 (1921); Austin, Bosquet, and Lazier, J. Am. Chem. Soc. 59, 864 (1937).
  3. Delfino and Somlo, IX Congr. intern. quím. pura applicada 4, 360 (1934) [C. A. 30, 2855 (1936)].
  4. E. I. du Pont de Nemours and Company, U. S. pat. 2,114,696 [C. A. 32, 4607 (1938)].
  5. Reissert, Ber. 46, 1489 (1913); Kalle and Company, A.-G., Ger. pat. 267,596 [Frdl. 11, 196 (1912-14)].

Appendix
Chemical Abstracts Nomenclature (Collective Index Number);
(Registry Number)

Congo red

ethyl acid phthalate

hydrochloric acid (7647-01-0)

ammonia (7664-41-7)

sodium hydroxide (1310-73-2)

sodium chloride (7647-14-5)

copper sulfate (7758-98-7)

phthalic anhydride (85-44-9)

zinc (7440-66-6)

Phthalimide (85-41-6)

ammonium phthalate (523-24-0)

Phthalide (87-41-2)

hydroxymethylbenzoic acid (612-20-4)

o-Toluic acid (118-90-1)