^
Top
Org. Synth. 1950, 30, 93
DOI: 10.15227/orgsyn.030.0093
cis4-TETRAHYDROPHTHALIC ANHYDRIDE
[4-Cyclohexene-1,2-dicarboxylic anhydride, cis-]
Submitted by Arthur C. Cope and Elbert C. Herrick1.
Checked by Charles C. Price, Kenneth N. Campbell, and Robert P. Kane.
1. Procedure
The apparatus shown in Fig. 16, consisting of a 2-l. three-necked round-bottomed flask fitted with an efficient stirrer (Note 1), a gas-inlet tube, a thermometer, and a reflux condenser, is assembled in a ventilated hood. Bubbler tubes containing benzene are attached to the gas inlet tube and the top of the reflux condenser, and 500 ml. of dry benzene and 196 g. (2 moles) of maleic anhydride (Note 2) are placed in the flask. Stirring is begun, the flask is heated with a pan of hot water, and butadiene is introduced (from a commercial cylinder controlled by a needle valve) at a rapid rate (0.6–0.8 l. per minute). When the temperature of the solution has reached 50° (within 3–5 minutes) the pan of water is removed. The exothermic reaction causes the temperature to reach 70–75° in 15–25 minutes. The rapid stream of butadiene is nearly completely absorbed for 30–40 minutes, after which the rate is decreased until the reaction is completed (equal rates of bubbling in the two bubbler tubes) after 2–2.5 hours. The solution is poured into a 1-l. beaker at once to avoid crystallization of the product in the reaction flask. The beaker is covered and the mixture is kept at 0–5° overnight.
The product is collected on a large Büchner funnel and washed with 250 ml. of 35–60° petroleum ether. A second crop (5–15 g.) obtained by diluting the filtrate with an additional 250 ml. of petroleum ether is separated by filtration, combined with the first crop in a large crystallizing dish, and dried to constant weight (1–2 hours) in an oven at 70–80°. The yield of cis4-tetrahydrophthalic anhydride is 281.5–294.5 g. (93–97%), m.p. 99–102° (Note 3).
Fig. 16. Assembly of apparatus for addition of butadiene to maleic anhydride.
Fig. 16. Assembly of apparatus for addition of butadiene to maleic anhydride.
2. Notes
1. Any stirrer that produces sufficiently vigorous agitation to disperse the gas through the liquid is satisfactory. It was found to be unnecessary to introduce the gas below the surface of the liquid.
2. A good grade of commercial maleic anhydride was used, m.p. 52–54°.
3. The product is analytically pure and suitable for use in preparing diethyl cis4-tetrahydrophthalate (p. 304). Recrystallization from ligroin2 or ether3 raises the m.p. to 103–104°.
Working with Hazardous Chemicals

The procedures in Organic Syntheses are intended for use only by persons with proper training in experimental organic chemistry. All hazardous materials should be handled using the standard procedures for work with chemicals described in references such as "Prudent Practices in the Laboratory" (The National Academies Press, Washington, D.C., 2011; the full text can be accessed free of charge at http://www.nap.edu/catalog.php?record_id=12654). All chemical waste should be disposed of in accordance with local regulations. For general guidelines for the management of chemical waste, see Chapter 8 of Prudent Practices.

In some articles in Organic Syntheses, chemical-specific hazards are highlighted in red "Caution Notes" within a procedure. It is important to recognize that the absence of a caution note does not imply that no significant hazards are associated with the chemicals involved in that procedure. Prior to performing a reaction, a thorough risk assessment should be carried out that includes a review of the potential hazards associated with each chemical and experimental operation on the scale that is planned for the procedure. Guidelines for carrying out a risk assessment and for analyzing the hazards associated with chemicals can be found in Chapter 4 of Prudent Practices.

The procedures described in Organic Syntheses are provided as published and are conducted at one's own risk. Organic Syntheses, Inc., its Editors, and its Board of Directors do not warrant or guarantee the safety of individuals using these procedures and hereby disclaim any liability for any injuries or damages claimed to have resulted from or related in any way to the procedures herein.

The paragraphs above were added in September, 2014. The statements above do not supersede any specific hazard caution notes and safety instructions included in the procedure.

3. Discussion
cis4-Tetrahydrophthalic anhydride has been prepared by the reaction of maleic anhydride and butadiene.2,3,4,5,6 The procedure described is adapted from the one used by Kohler and Jansen.5
This preparation is referenced from:

References and Notes
  1. Massachusetts Institute of Technology, Cambridge, Massachusetts.
  2. Diels and Alder, Ann., 460, 113 (1928).
  3. Jenkins and Costello, J. Am. Chem. Soc., 68, 2733 (1946).
  4. Farmer and Warren, J. Chem. Soc., 1929, 903.
  5. Kohler and Jansen, J. Am. Chem. Soc., 60, 2144 (1938); Cope and Herrick, J. Am. Chem. Soc., 72, 983 (1950).
  6. Fieser and Novello, J. Am. Chem. Soc., 64, 806 (1942).

Appendix
Chemical Abstracts Nomenclature (Collective Index Number);
(Registry Number)

ligroin

petroleum ether

Diethyl cis-Δ4-tetrahydrophthalate

cis-Δ4-Tetrahydrophthalic anhydride

Benzene (71-43-2)

butadiene (106-99-0)

maleic anhydride (108-31-6)

4-Cyclohexene-1,2-dicarboxylic anhydride, cis- (935-79-5)

Notes

1. Any stirrer that produces sufficiently vigorous agitation to disperse the gas through the liquid is satisfactory. It was found to be unnecessary to introduce the gas below the surface of the liquid.

2. A good grade of commercial maleic anhydride was used, m.p. 52–54°.

3. The product is analytically pure and suitable for use in preparing diethyl cis4-tetrahydrophthalate (p. 304). Recrystallization from ligroin2 or ether3 raises the m.p. to 103–104°.

References/EndNotes

Article Compounds

Authors