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Org. Synth. 1977, 57, 83
DOI: 10.15227/orgsyn.057.0083
3-PHENYL-2H-AZIRINE-2-CARBOXALDEHYDE
[2H-Azirine-2-carboxaldehyde, 3-phenyl-]
Submitted by Albert Padwa1, Thomas Blacklock, and Alan Tremper.
Checked by W. F. Oettle, E. R. Holler, and William A. Sheppard.
1. Procedure
Caution! Although the organic azide intermediates used in this procedure have not shown any explosive hazard under the experimental conditions, they should always be handled with adequate shielding and normal protective equipment such as face shield and leather gloves.
A. (1-Azido-2-iodo-3,3-dimethoxypropyl)benzene. A dry, 1-l., three-necked, round-bottomed flask fitted with an efficient magnetic stirrer and two 250-ml. pressure-equalizing dropping funnels charged with 75 g. (1.l moles) of sodium azide and 450 ml. of dry acetonitrile (Note 1). The mixture is stirred and cooled in an ice–salt bath (−5° to 0°), and 83 g. (0.51 mole) of iodine monochloride (Note 2) is added dropwise from one of the addition funnels over 10–20 minutes. The solution is stirred for an additional 5–10 minutes before 81 g. (0.45 mole) of cinnamaldehyde dimethyl acetal (Note 3) is added from the other dropping funnel over a 15–20 minute period, while the cooling bath temperature is maintained at 0–5°. The resulting red-brown mixture is stirred for 12 hours at room temperature, poured into 500 ml. of water, and extracted with three 500-ml. portions of diethyl ether. The combined organic extracts are washed successively with 700 ml. of 5% aqueous sodium thiosulfate (Note 4) and 1 l. of water. The ether solution in dried over magnesium sulfate. The solvent is removed with a rotary evaporator, giving the azide product as a orange oil (Note 5), 150–156 g. (97–98%), of sufficient purity to be used for the next step.
B. (1-Azido-3,3-dimethoxy-1-propenyl)benzene. A 2-l., one-necked, round-bottomed flask equipped with a magnetic stirrer and powder funnel is charged with 156 g. (0.450 mole) of the iodoazide from Part A and 1500 ml. of anhydrous ether. The solution is stirred and cooled in an ice-salt bath (−5° to 0°), and 62 g. (0.55 mole) of potassium tert-butoxide (Note 6) is added. The powder funnel is replaced with a calcium chloride drying tube and the mixture is stirred for 4–5 hours at 0° , at which time 350 ml. of water is added while the mixture is still cold. The ethereal layer is separated, washed with three 350-ml. portions of water, and dried over magnesium sulfate. The solvent is removed with a rotary evaporator without heating, leaving 67–75 g. (68–76%) of (1-azido-3,3-dimethoxy-1-propenyl)-benzene as a dark oily liquid (Note 7), which can be used without further purification for Part C (Note 8).
C. 2-(Dimethoxymethyl)-3-phenyl-2H-azirine. The crude product (71–75 g., 0.32–0.34 mole) obtained from Part B is heated at reflux in 1 l. of chloroform in a 2-l., round-bottomed flask for 12 hours (Note 9). The solvent is removed with a rotary evaporator and the crude residue is distilled, giving 48–61 g. (78–93%) of 2-(dimethoxymethyl)-3-phenyl-2H-azirine, b.p. 103–105° (0.27 mm.) as a colorless oil (Note 10).
D. 3-Phenyl-2H-azirine-2-carboxaldehyde. The product from Part C (59.0 g., 0.31 mole) is placed in a 3-l., three-necked, round-bottomed flask fitted with a mechanical stirrer, a reflux condenser, and a thermometer of sufficient length to extend into the liquid contents of the flask. After addition of 600 ml. of 1,4-dioxane (Note 11) and 800 ml. of 20% acetic acid, the mixture is stirred and heated sufficiently to bring the temperature of the reaction mixture up to 90° over a period of one hour (Note 12). The temperature of the reaction mixture is held at 90° for an additional 5 minutes, then the flask is rapidly cooled in an ice-salt bath (−5° to 0°). The product is extracted with four 1-l. portions of ether, and the combined organic extracts are washed successively with 1 l. of 5% aqueous sodium hydrogen carbonate and 1-l. of saturated aqueous sodium chloride. After the ether layer has been dried over anhydrous magnesium sulfate, the solvent is removed with a rotary evaporator, and a mixture of 5 ml. of ether and 10 ml. of pentane is added. The residual oil is allowed to stand in a refrigerator (0–3°) for 12 hours, completing the crystallization of the crude product. The crystalline solid is collected on a cold filter and sublimed at 35° (0.01 mm.), giving 13.3 g. (30%) (Note 13) of 3-phenyl-2H-azirine-2-carboxaldehyde, m.p. 49–51° (Note 14).
2. Notes
1. Reagent grade acetonitrile (J. T. Baker Chemical Company) was used without further purification.
2. Iodine monochloride, purchased from J. T. Baker Chemical Company, was used without further purification.
3. Cinnamaldehyde dimethyl acetal was prepared by the method used to prepare the corresponding diethyl acetal.2 A mixture of 66.0 g. (0.50 mole) of trans-cinnamaldehyde (Aldrich Chemical Company, Inc.), 100 g. (1.06 mole) of trimethyl orthoformate (Eastman Organic Chemicals), 450 ml. of anhydrous methanol (J. T. Baker Chemical Company), and 0.5 g. of p-toluenesulfonic acid monohydrate (Fisher Scientific Company) is stirred at room temperature for 24 hours. At the end of this time, the alcohol is removed with a rotary evaporator, and the residue is distilled, giving 81–83 g. (91–93%) of cinnamaldehyde dimethyl acetal, b.p. 93–96° (0.2 mm.).
4. The orange color of the ethereal solution is completely discharged after washing with 5% aqueous sodium thiosulfate.
5. The product has the following spectral properties: IR (neat) cm.−1: 2120 (strong N3 absorption); 1H NMR (CDCl3), δ (multiplicity, coupling constant J in Hz., number of protons, assignment): 3.38 (s, 3H, OCH3), 3.46 (s, 3H, OCH3), 3.93 (d, J = 4, 1H, 1- or 3-CH), 4.38 (d of d, J = 9 and 4, 1H, CHI) 4.78 (d, J = 9, 1H, 1- or 3-CH), 7.33 (s, 5H, C6H5).
6. Potassium tert-butoxide, purchased from Columbia Organic Chemicals Company, Inc., was sublimed at 150° (0.02 mm.) before use and was added in one portion.
7. The submitters reported a yield of 94–96 g. (97–98%). The spectral properties of the product are: IR (neat) cm.−1: 2151 and 1642; 1H NMR (CDCl3), δ (multiplicity, coupling constant J in Hz., number of protons, assignment): 3.26 (s, 6H, 2 OCH3), 4.78 [d, J = 8, 1H, CH(OCH3)2], 5.60 (d, J = 8, 1H, CH), 7.45 (s, 5H, C6H5).
8. The intermediate vinyl azide should either be used immediately or stored cold in a vented container, since it slowly evolves nitrogen on standing at room temperature.
9. The reaction can be conveniently monitored by IR spectroscopy by observing the intensity of the band at 2150 cm.−1 (N3).
10. The spectral properties are: IR (neat) cm.−1: 1754 (azirine); 1H NMR (CDCl3), δ (multiplicity, coupling constant J in Hz., number of protons, assignment): 2.38 (d, J = 3, 1H, CH), 3.35 (s, 3H, OCH3), 3.47 (s, 3H, OCH3), 4.39 [d, J = 3, 1H, CH(OCH3)2], 7.3–8.0 (m, 5H, C6H5).
11. 1,4-Dioxane available from Fisher Scientific Company was used without further purification.
12. The mixture is brought to 90° by heating at a rate of 1° per minute. The mixture must not be overheated, or else the final product will be very difficult to crystallize.
13. Starting with 45.3 g. (0.237 mole) of the dimethyl acetal from Part C, the checkers obtained 10.2 g. (30%) of the product.
14. The submitters reported a yield of 35–38 g. (55–60%) based on 78–84 g. of starting material and using appropriate proportions of reagents. Their product had m.p. 45–47°. The spectral properties of the azirine product are: IR (KBr) cm.−1 1786 and 1709; 1H NMR (CDCl3), δ (multiplicity, coupling constant J in Hz., number of protons, assignment): 2.89 (d, J = 7, 1H, CH), 7.5–8.0 (m, 5H, C6H5), 9.04 (d, J = 7, 1H, CHO).
3. Discussion
The formation of substituted azirines by the thermal decomposition of vinyl azides is a general reaction.3 Iodine azide offers an excellent route to vinyl azides;4,5 it adds to many olefinic compounds, giving α iodoazides which can easily eliminate hydrogen iodide upon treatment with base. The direction of iodine azide addition is consistent with electrophilic attack of I⊕, giving a cyclic iodonium ion which is opened by azide ion. The presence of the dimethyl acetal moiety in the system above does not not interfere with the iodine azide reaction. This procedure does not work with trans-cinnamaldehyde, owing to a competing aldol condensation in the elimination step.
The aldehyde functionality present in 3-phenyl-2H-azirine-2-carboxaldehyde reacts selectively with amines, and Grignard and Wittig reagents, yielding a variety of substituted azirines,6 which have been used, in turn, to prepare a wide assortment of heterocyclic rings such as oxazoles, imidazoles, pyrazoles, pyrroles, and benzazepins.6,7
In addition to the present method, 2H-azirines can be prepared by a modified Neber reaction,8,9,10 or by heating 4,5-dihydro-1,2,5-oxazaphospholes.11,12,13,14

References and Notes
  1. Chemistry Department, State University of New York at Buffalo, Buffalo, N.Y. 14214. [Present address: Department of Chemistry, Emory University, Atlanta, Georgia 30322].
  2. J. Klein and E. D. Bergmann, J. Am. Chem. Soc., 79, 3452 (1957).
  3. F. W. Fowler, Adv. Heterocycl. Chem., 13, 45 (1971).
  4. A. Hassner and L. A. Levy, J. Am. Chem. Soc., 87, 4203 (1965).
  5. F. W. Fowler, A. Hassner, and L. A. Levy, J. Am. Chem. Soc., 89, 2077 (1967).
  6. A. Padwa, J. Smolanoff, and A. Tremper, Tetrahedron Lett., 29 (1974).
  7. A. Padwa and J. Smolanoff, Tetrahedron Lett., 33 (1974).
  8. R. F. Parcell, Chem. Ind. (London), 1396 (1963).
  9. S. Sato, Bull. Chem. Soc. Jpn., 41, 1440 (1968).
  10. G. Alvernhe, S. Arsenyiadis, R. Chaabouni, and A. Laurent, Tetrahedron Lett., 355 (1975).
  11. H. J. Bestmann and R. Kunstmann, Angew, Chem. Int. Ed. Engl., 5, 1039 (1966).
  12. H. J. Bestmann and R. Kunstmann, Chem. Ber., 102, 1816 (1969).
  13. R. Huisgen and J. Wulff, Tetrahedron Lett., 917 (1967).
  14. R. Huisgen and J. Wulff, Chem. Ber., 102, 1833 (1969).

Appendix
Chemical Abstracts Nomenclature (Collective Index Number);
(Registry Number)

acetic acid (64-19-7)

methanol (67-56-1)

ether,
diethyl ether (60-29-7)

acetonitrile (75-05-8)

chloroform (67-66-3)

sodium hydrogen carbonate (144-55-8)

sodium chloride (7647-14-5)

sodium thiosulfate (7772-98-7)

nitrogen (7727-37-9)

hydrogen iodide (10034-85-2)

Pentane (109-66-0)

sodium azide (26628-22-8)

magnesium sulfate (7487-88-9)

iodine monochloride (7790-99-0)

1,4-dioxane (123-91-1)

cinnamaldehyde dimethyl acetal

Iodine azide

(1-azido-3,3-dimethoxy-1-propenyl)-benzene,
(1-Azido-3,3-dimethoxy-1-propenyl)benzene (56900-67-5)

trimethyl orthoformate (149-73-5)

p-toluenesulfonic acid monohydrate (6192-52-5)

potassium tert-butoxide (865-47-4)

trans-cinnamaldehyde (104-55-2)

3-Phenyl-2H-azirine-2-carboxaldehyde,
2H-Azirine-2-carboxaldehyde, 3-phenyl- (42970-55-8)

2-(Dimethoxymethyl)-3-phenyl-2H-azirine (56900-68-6)

(1-Azido-2-iodo-3,3-dimethoxypropyl)benzene (56900-66-4)