Org. Synth. 1922, 2, 13
Submitted by J. B. Conant and O. R. Quayle.
Checked by O. Kamm, A. D. Dox, and L. Yoder.
In a 2-l. flask
are placed 375 g. (1.3 moles) of commercial sodium dichromate (Note 1)
, 225 cc. of water, and 300 g. (2.3 moles) of glycerol α,γ-dichlorohydrin (p. 292)
(b.p. 68–75°/14 mm.
). The flask is set in a water bath
and equipped with a thermometer
and a mechanical stirrer (Note 2)
. The contents are vigorously stirred, and 450 g. (245 cc.) of concentrated sulfuric acid
, diluted with 115 g. of water, are introduced during the course of seven to eight hours. It is convenient to add the acid at ten-minute intervals. The temperature is kept between 20° and 25° during the entire reaction; this is accomplished by adding a little ice to the water bath from time to time. The stirring is continued for sixteen to seventeen hours after all the acid has been added; as there is very little heat evolved during this part of the reaction, the water bath may be allowed to come to room temperature (Note 3)
Sufficient water (300–800 cc.) is now added to the mixture to dissolve the pasty chromium salts (Note 4). The mass of crystals is then rapidly filtered on a Büchner funnel and sucked as dry as possible. The crystals are then transferred to a small laboratory centrifuge and centrifuged for several minutes. The crystals are washed in the centrifuge with about 15–25 cc. of ice water, then with 10–15 cc. of cold petroleum ether, and finally centrifuged until as dry as possible (Note 5). The crude dichloroacetone is dried in a vacuum desiccator over sulfuric acid overnight. It weighs about 220 g.
The crude product is best purified by distillation from a 250-cc. distilling flask fitted with an air condenser. A very small fraction (10–15 g.) of low-boiling material is obtained, and the dichloroacetone (170–175°) is then collected. It solidifies in the receiver to a white crystalline mass which weighs 200–220 g. (68–75 per cent of the theoretical amount). A few grams more may be obtained by chilling the low-boiling fraction and filtering off the water.
Commercial sodium dichromate
is hygroscopic and contains varying amounts of water. The 375 g. required in these directions is equivalent to 319 g. of anhydrous material.
Great caution should be exercised in working with dichloroacetone
, as it is extremely lachrymatory and blisters the skin.
The total time required for the oxidation is twenty-four hours. It is convenient to start the reaction in the morning. In this way the last part of the reaction, which requires no attention, will be accomplished during the night. The regulation of the temperature is necessary, as the reaction proceeds very slowly below 20°; on the other hand, the dichloroacetone
itself is oxidized at a somewhat higher temperature than 25°.
In transferring the crystals from the reaction flask to the Büchner funnel it is necessary to use a certain amount of water to dissolve the pasty chromium salts
which are otherwise quite impossible to filter. The amount necessary varies greatly in different runs, according to the manner in which the chromium salts
separate. The amount of this water is kept low in order to dissolve as little of the product as possible. Nevertheless, 10–15 g.
are thus dissolved; this material, together with a little unchanged dichlorohydrin
, may be recovered by a long procedure involving extraction with ether
and sodium bisulfite
. This is not profitable, however.
It is not necessary to wash the crystals in the centrifuge until they are white. A small amount of chromic salt
will not interfere with the subsequent purification.
can be prepared by the direct chlorination of acetone
by the oxidation of glycerol α,γ-dichlorohydrin
by the action of hypochlorous acid
and by the action of sulfur monochloride
This preparation is referenced from:
Chemical Abstracts Nomenclature (Collective Index Number);
sulfuric acid (7664-93-9)
sodium bisulfite (7631-90-5)
sodium dichromate (7789-12-0)
hypochlorous acid (7790-92-3)
2-Propanone, 1,3-dichloro- (534-07-6)
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