Org. Synth. 1935, 15, 48
[I. (From Methylamine Hydrochloride)]
Submitted by F. Arndt
Checked by C. R. Noller and S. Lieberman.
In a tared 1-l. flask is placed 200 g. (1.5 moles) of 24 per cent aqueous methylamine solution (Note 1), and concentrated hydrochloric acid is added until the solution is acid to methyl red; about 155 cc. of acid is required. Water is added to bring the total weight to 500 g., 300 g. (5 moles) of urea is added, and the solution is boiled gently under reflux for two and three-quarters hours and then vigorously for one-quarter hour. The solution is cooled to room temperature, 110 g. (1.5 moles) of 95 per cent sodium nitrite is dissolved in it, and the whole is cooled to 0°. A mixture of 600 g. of ice and 100 g. (1 mole) of concentrated sulfuric acid in a 3-l. beaker is surrounded by an efficient freezing mixture, and the cold methylurea-nitrite solution is run in slowly with mechanical stirring at such a rate that the temperature does not rise above 0° (Note 2).
The nitrosomethylurea rises to the surface as a crystalline foamy precipitate which is filtered at once with suction and pressed well on the filter. The crystals are stirred to a paste with about 50 cc. of cold water, sucked as dry as possible (Note 3), and dried in a vacuum desiccator to constant weight. The yield is 105–115 g. (66–72 per cent of the theoretical amount) (Note 4).
content of the commercial aqueous solution (Röhm and Haas) was determined by titration with standard acid using methyl red
as indicator. If the methylamine
content is found to be different an equivalent quantity is used.
It is convenient to keep the methylurea-nitrite
solution in an ice-salt bath
and to siphon it into the acid solution, the end of the siphon dipping below the surface. About one hour is required for the addition.
A sample of the moist product should dissolve completely in boiling methyl alcohol
. If an appreciable residue remains, which is not usually the case, the washing process is repeated. Each successive washing decreases the yield somewhat.
The preparation obtained in this way may be kept indefinitely in a refrigerator. It should not be kept above 20° for more than a few hours. At temperatures in the neighborhood of 30° it may undergo a sudden decomposition without explosion but with the evolution of irritating fumes. It has been reported that the stability is increased by the addition of a few drops of acetic acid
[II. (From Acetamide)]
Submitted by E. D. Amstutz and R. R. Myers.
Checked by C. F. H. Allen and J. Dec.
(A) Acetyl Methylurea.—To a solution (Note 1) of 59 g. (1 mole) of acetamide in 88 g. (0.55 mole) of bromine in a 4-l. beaker is added, dropwise and with hand stirring, a solution of 40 g. (1 mole) of sodium hydroxide in 160 cc. of water. The resulting yellow reaction mixture is heated on a steam bath until effervescence sets in (Note 2), after which heating is continued for an additional two to three minutes. Crystallization of the product from the yellow to red colored solution usually commences immediately (Note 3) and is completed by cooling in an ice bath for one hour. The weight of the white crystalline acetyl methylurea obtained by filtration and air drying is 49–52 g. (84–90 per cent of the theoretical amount) (Note 4)(Note 5). It melts at 169–170°.
(B) Nitrosomethylurea.—A mixture of 49 g. (0.42 mole) of acetyl methylurea (Note 6) and 50 cc. of concentrated hydrochloric acid is heated, with hand stirring, on a steam bath until it is apparent that no more solid (Note 5) is dissolving. Heating is continued for three or four minutes longer (total time on steam bath—eight to twelve minutes), after which the solution is diluted with an equal volume of water and cooled below 10° in an ice bath. A cold saturated solution of 38 g. (0.55 mole) of sodium nitrite in 55 cc. of water is then run in slowly with stirring. The mixture is allowed to remain in the ice bath for several minutes, after which the nitrosomethylurea is filtered and washed with about 8–10 cc. of ice-cold water. Air drying gives 33–36 g. (76–82 per cent of the theoretical amount) of nitrosomethylurea as pale yellow crystals melting at 123–124°.
Gentle heating on a steam bath assists in dissolving the acetamide
. Care is necessary, however, to see that only the minimum amount of bromine
is lost during the heating.
Occasionally this effervescence becomes quite brisk, and for this reason a large container
If the solution at this point is perfectly colorless, the product is usually slower in crystallizing, it contains more sodium bromide
, and the yield is somewhat lower. For these reasons, the slight excess of bromine
used is necessary.
When the crude yield is the lower figure given, the remainder of the product can be secured by long cooling of the filtrate in ice.
The crude acetyl methylurea
contains some sodium bromide
, which appears as a white crystalline material insoluble in concentrated hydrochloric acid
in Part (B
). The sodium bromide
dissolves when the solution is diluted and has no effect upon the subsequent treatment with sodium nitrite
The acetyl methylurea
prepared in Part (A
) may be used without drying.
is always prepared by the nitrosation of methylurea
, in turn, can be prepared from (a
) methylamine hydrochloride
and potassium cyanate
) methyl sulfate
, and potassium cyanate
) methylamine hydrochloride
, and alkali.3
Checked directions for preparing methylurea
, and for its subsequent nitrosation, according to (a
) and (b
) are described on p. 48 of Volume 15 of Organic Syntheses
. The preparation of methylurea
, and its subsequent nitrosation, according to (c
) and (d
) are given in procedures I and II, above. The preparations using potassium cyanate
suffer because of the difficulty and the expense of obtaining that reagent. Arndt, Loewe, and Avan2
have discussed the merits of the different methods of preparing nitrosomethylurea
This preparation is referenced from:
Chemical Abstracts Nomenclature (Collective Index Number);
sulfuric acid (7664-93-9)
hydrochloric acid (7647-01-0)
acetic acid (64-19-7)
methyl alcohol (67-56-1)
sodium hydroxide (1310-73-2)
sodium bromide (7647-15-6)
sodium nitrite (7632-00-0)
methyl sulfate (75-93-4)
Methylamine hydrochloride (593-51-1)
potassium cyanate (590-28-3)
Acetyl methylurea (623-59-6)
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