Org. Synth. 1946, 26, 28
[2-Naphthoic acid, 3,4-dihydro-6,7-dimethoxy-]
Submitted by H. L. Holmes and L. W. Trevoy.
Checked by Cliff S. Hamilton and Carol K. Ikeda.
A. Ester condensation
. A suspension of 9.40 g. (0.41 gram atom) of powdered sodium1
in 100 ml. of absolute ether
is placed in a 1-l. three-necked flask (Note 1)
fitted with a reflux condenser
, dropping funnel
, and a calcium chloride tube
. A solution of 23.8 ml. (0.41 mole) of absolute ethanol (Note 2)
in 50 ml. of absolute ether
is added through the dropping funnel, and the mixture is refluxed on a steam bath
for 10–11 hours. The reflux condenser is replaced by a mercury-seal stirrer
. A thermometer
and a calcium chloride tube are fitted into the third neck of the flask. The suspension of sodium ethoxide
in absolute ether
is cooled to −10° to −15° in an ice-hydrochloric acid bath
, and a solution of 47.85 g. (0.19 mole) of ethyl γ-veratrylbutyrate (Note 3)
and 29.6 g. (0.40 mole) of ethyl formate
in 100 ml. of absolute ether
is added dropwise through the dropping funnel with vigorous stirring (Note 4)
. The mixture is kept at −10° for 4 hours, and then the thermometer and calcium chloride tube are removed and the stirrer is replaced by a reflux condenser equipped with a calcium chloride tube. The mixture is allowed to come to room temperature and stand for 72 hours. During this time a gas is evolved and a pale yellow solid separates.
On digestion of this solid mass with 1 l. of ice and water, the sodium salt of the enol dissolves in the water, and the unreacted ester is removed by extracting the aqueous layer with two 200-ml. portions of ether (Note 5). The formyl derivative settles out as an oil upon acidification of the aqueous layer with dilute sulfuric acid. The oil is extracted with three 200-ml. portions of ether, and the ethereal extract is washed several times with water and dried over anhydrous sodium sulfate. The ether is distilled, and, to remove traces of ethyl formate, the oil is heated on a steam bath under a pressure of 20–30 mm. for 1 hour. The remaining yellow formyl derivative weighs 27–29 g. (Note 6).
B. Cyclization. The above oil is poured dropwise into a well-stirred mixture of 110 ml. of 90% phosphoric acid (sp. gr. 1.75) and 23.4 ml. of sulfuric acid (sp. gr. 1.83) which is kept at −10°. The temperature is allowed to rise to 0–10°, and the stirring is continued for 2 hours. The viscous reaction mixture is poured into 500 ml. of ice and water, and the acid is partially neutralized with 300 ml. of 40% sodium hydroxide solution with efficient cooling. The viscous cream-colored oil is extracted with three 150-ml. portions of ether; the ether extract is washed well with water and sodium bicarbonate solution to remove the last traces of acid and then dried over anhydrous sodium sulfate. The cyclized ester, after removal of the ether, is a red oil which solidifies upon cooling. The yield is 23–24 g.
C. Saponification. The ester is saponified by refluxing for 5 hours with 75 ml. of a 10% sodium hydroxide solution containing 3 ml. of ethanol; it is then poured into 150 ml. of water and decolorized with Norit. Upon acidification of the alkaline solution with dilute hydrochloric acid, 18–19 g. (40–43%) (Note 7) and (Note 8) of acid is obtained, melting at 191–193° (cor.).
It is suggested that a flask with a ground-glass joint be employed for the condensation as it leads to less discoloration of the formylation product.
The absolute ethanol
employed in the condensation was refluxed over calcium oxide
for 20 hours and finally distilled from magnesium ethoxide
The ethyl γ-veratrylbutyrate
, b.p. 203–207°/20 mm
., is obtained in 80%
yield by esterification of γ-veratrylbutyric acid
by the Fischer-Speier method. The γ-veratrylbutyric acid
is prepared by the method of E. L. Martin2
from β-(3,4-dimethoxybenzoyl) propionic acid
The ethereal solution of the two esters should be added at such a rate that the addition is complete in about 1 hour.
On distillation, after removal of the ether
, 18–20 g.
of the ethyl γ-veratrylbutyrate
The formylation product is too sensitive to purify by distillation even at pressures of 1–2 mm. of mercury
In a similar manner, 3,4-dihydro-2-naphthoic acid
, m.p. 111–114°
(cor.), and 7-methoxy-3,4-dihydro-2-naphthoic acid
, m.p. 149–150.5°
(cor.), have been obtained in 35% yields.
can be dehydrogenated3
to give 6,7-dimethoxy-2-naphthoic acid
. The yield of the latter was 85%
after distillation and crystallization from ethanol
This method of preparation is essentially that used by Robinson and Crowley4
for the preparation of 6-methoxy-3,4-dihydro-2-naphthoic acid
. They first used concentrated sulfuric acid
but found that this reagent caused sulfonation.
Chemical Abstracts Nomenclature (Collective Index Number);
sulfuric acid (7664-93-9)
hydrochloric acid (7647-01-0)
sodium hydroxide (1310-73-2)
sodium bicarbonate (144-55-8)
sodium sulfate (7757-82-6)
phosphoric acid (7664-38-2)
sodium ethoxide (141-52-6)
ethyl formate (109-94-4)
2-Naphthoic acid, 3,4-dihydro-6,7-dimethoxy- (53684-50-7)
magnesium ethoxide (2414-98-4)
β-(3,4-dimethoxybenzoyl) propionic acid
sodium salt (824-79-3)
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