Org. Synth. 1953, 33, 43
Submitted by Werner R. Boehme1
Checked by James Cason and Kenneth L. Rinehart.
A. Ethyl 3-methylcoumarilate. Dry sodium phenolate (116 g., 1 mole) (Note 1) and 1 l. of dry thiophene-free benzene (Note 2) are placed in a 2-l. three-necked flask fitted with mechanical stirrer, dropping funnel, and reflux condenser with drying tube. The suspension is heated to the boiling point on the steam bath, heating is moderated, and 165 g. (1 mole) of ethyl α-chloroacetoacetate (Note 3) is added with stirring through the dropping funnel at such a rate as to maintain gentle refluxing (Note 4). Refluxing and stirring are continued on the steam bath for 4 hours after the addition of the chloroester has been completed. The light brown suspension is cooled to room temperature, extracted with two 500-ml. portions of water, and dried superficially by filtration through a layer of anhydrous magnesium sulfate. The solvent is removed by distillation on the steam bath under water-aspirator vacuum. The brown oil remaining consists of crude ethyl α-phenoxyacetoacetate and weighs 188–200 g. (85–90%).
Concentrated sulfuric acid (195 ml.) is placed in a 2-l. three-necked flask immersed in an ice-salt bath and fitted with a dropping funnel, a thermometer, and a mechanical stirrer. Ethyl α-phenoxyacetoacetate (195 g.) is added with stirring through the dropping funnel while the temperature within the flask is maintained below 5°. About 1 hour is required for the addition. The mixture, which solidifies soon after all the ester has been added, is allowed to stand in the ice bath for 1 hour longer. Ice (500 g.) and water (500 ml.) are added with stirring and external cooling. The mixture is then extracted with two 250-ml. portions of benzene. The combined extracts are washed with 100 ml. of water, then with 100 ml. of saturated aqueous sodium bi-carbonate solution, and finally are dried superficially by filtration through a layer of anhydrous magnesium sulfate. The solvent is distilled from the dried extracts, and the residue is fractionated under reduced pressure from a 250-ml. Claisen flask fitted with a short air condenser. The pale-yellow oil boils at 162–167°/16 mm. and solidifies on cooling. The product is triturated with a little petroleum ether (b.p. 35–60°) and dried at room temperature. The almost colorless rhombic plates, melting at 49–51°, weigh 60–75 g. (34–42%).
B. 3-Methylcoumarilic acid. Ethyl 3-methylcoumarilate (70 g.) and 500 ml. of 10% aqueous potassium hydroxide solution are refluxed for 1 hour. The clear yellowish solution is acidified while hot (Note 5) with a slight excess of concentrated hydrochloric acid to precipitate the 3-methylcoumarilic acid. The suspension is cooled to room temperature, and the colorless solid is filtered with suction. The filter cake is resuspended in 500 ml. of cold water, stirred vigorously for several minutes, and filtered again with suction. The colorless powder, after being dried in a desiccator under reduced pressure, weighs 54–57 g. (90–95%) and melts at 192–193°.
C. 3-Methylcoumarone. Dry 3-methylcoumarilic acid (50 g.) is distilled from a 250-ml. Claisen flask fitted with a long air condenser and immersed in a Wood's metal bath heated slowly to 280°. Carbon dioxide is evolved, and a cloudy liquid distils at 190–220°. The crude product is purified by redistillation through a Vigreux column (Note 6). The clear colorless distillate, weighing 31.5–33 g. (84–88%), boils at 195–197°, nD25 1.5520.
may be prepared in situ
by evaporating molar equivalents of phenol
and sodium hydroxide
solution in the reaction flask on the steam bath under reduced pressure and drying the residue by heating the flask for several hours longer on the steam bath under reduced pressure. The solid cake of dry sodium phenolate
breaks up in the succeeding step of the synthesis.
is conveniently dried by slowly distilling about 20% of it and cooling the residue with protection from atmospheric moisture by use of a calcium chloride tube
is prepared by the general method of Allihn.2 Caution! Since the substance is a severe lachrymator and gases evolved during the preparation are difficult to absorb, the entire preparation should be carried out in a hood.
In a 1-l. three-necked flask fitted with dropping funnel, a thermometer, and a mechanical stirrer, and connected to a gas-absorption trap
is placed 260 g. (2 moles) of technical grade ethyl acetoacetate
. Sulfuryl chloride (270 g., 2 moles)
is added slowly with stirring and external cooling, the temperature being maintained between 0° and 5°. About 3 hours is required for the addition. The solution is allowed to stand overnight at room temperature, and hydrogen chloride
and sulfur dioxide
are removed at 40–50° under water-aspirator vacuum. The residual dark-amber liquid is distilled through a short Vigreux column
at reduced pressure. After a small fore-run, the ethyl α-chloroacetoacetate
distils at 85–89°/17 mm.
The yield of colorless liquid is 308–321 g.
). The checkers, using a 12-cm. unheated Vigreux column
, obtained this yield only after redistilling the combined fore-run and after-run. Ethyl α-chloroacetoacetate is currently available from Distillation Products Industries, Rochester, New York
The time of addition is 20–30 minutes. Some external heating is usually necessary to maintain reflux during the addition.
If the solution is allowed to cool much below 70° the potassium salt of 3-methylcoumarilic acid
crystallizes in the form of colorless needles.
The checkers used an 18-in. Podbielniak column with simple wire spiral, heated jacket, and partial-reflux head
has been prepared by the cyclization of ethyl α-phenoxyacetoacetate
followed by hydrolysis and de-carboxylation of the resulting ethyl 3-methylcoumarilate
by debromination and rearrangement of 3,4-dibromo-4-methyl-coumarin
to 3-methylcoumarilic acid
followed by decarboxylation,4,5
by cyclization of phenoxyacetone
with concentrated sulfuric acid
and by treatment of 3-coumaranone
with methyl-magnesium iodide
followed by dehydration of the resulting carbinol.7
The procedure described is a modification of the method of Hantzsch.4
Chemical Abstracts Nomenclature (Collective Index Number);
sulfuric acid (7664-93-9)
hydrochloric acid (7647-01-0)
sodium hydroxide (1310-73-2)
sulfur dioxide (7446-09-5)
carbon dioxide (124-38-9)
sulfuryl chloride (7791-25-5)
potassium hydroxide (1310-58-3)
methyl-magnesium iodide (917-64-6)
Ethyl acetoacetate (141-97-9)
magnesium sulfate (7487-88-9)
Benzofuran, 3-methyl- (21535-97-7)
ethyl α-chloroacetoacetate (609-15-4)
Ethyl 3-methylcoumarilate (22367-82-4)
3-Methylcoumarilic acid (24673-56-1)
potassium salt of 3-methylcoumarilic acid
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