Org. Synth. 1969, 49, 18
[Thiirane, 2-chloro-, 1,1-dioxide]
Submitted by Leo A. Paquette and Lawrence S. Wittenbrook1
Checked by John J. Miller and William D. Emmons.
Caution! Because of the toxic nature of chlorine
and the lachrymatory properties of chloromethanesulfonyl chloride
, both steps of this preparation should be carried out in a well-ventilated hood
is also explosive; follow the directions for its handling given in earlier volumes.2,3
A. Chloromethanesulfonyl chloride. A slurry of 210 g. (1.52 moles) of s-trithiane (Note 1) in a mixture of 1 l. of glacial acetic acid and 210 ml. of water is prepared in a 2-l., three-necked, round-bottomed flask equipped with an efficient mechanical stirrer, a thermometer, a coarsely fritted gas inlet tube (Note 2). and an exit tube by which excess fumes are carried to the rear of the hood. The flask is immersed in an ice bath, and the stirrer is started. A stream of chlorine is introduced at such a rate (Note 3) that the temperature of the mixture is maintained between 40° and 50° by the mildly exothermic reaction. After 1–2 hours a yellow solution results. To this solution is added 300 ml. of water, at which point the temperature rises to ca. 60°.
Chlorine is again introduced, and the stirred reaction mixture is cooled to maintain the temperature initially in the vicinity of 40°. During 3 hours the temperature slowly returns to that of the surroundings, and the stream of chlorine is stopped. The yellow solution is allowed to stand overnight at room temperature and is then transferred to a 4-l. Erlenmeyer flask and diluted with 1.5 l. of ice water. The flask is stoppered and placed in a refrigerator for 2–3 hours. The aqueous phase is decanted from the denser, organic layer that has separated (Note 4) and is extracted with four 300-ml. portions of methylene chloride. The methylene chloride extracts are combined with the original organic layer, dried over anhydrous magnesium sulfate, filtered, and evaporated on a rotary evaporator at 20–30°. The material that remains is distilled through a 15-cm. Vigreux column. Chloromethanesulfonyl chloride is collected as a colorless, lachrymatory liquid, b.p. 80–81° (25 mm.), n26D 1.4840–1.4850; yield 135–220 g. (20–32%) (Note 5).
B. 2-Chlorothiirane 1,1-dioxide. In a 500-ml., three-necked, round-bottomed flask fitted with an efficient mechanical stirrer, a thermometer, and two pressure-equalizing addition funnels is placed an ethereal solution of 4.6 g. (0.11 mole) of diazomethane (Note 6). The system is blanked with nitrogen, the stirrer is started, and the solution is cooled to −10° with an ice-methanol bath. A solution of 14.9 g. (0.100 mole) of chloromethanesulfonyl chloride in 40 ml. of ether and a solution of 10.0 g. (0.099 mole) of triethylamine in 40 ml. of ether are simultaneously added dropwise from the two addition funnels. The addition requires about 45 minutes. The insoluble triethylamine hydrochloride is separated by filtration and washed with 25 ml. of cold ether. The combined filtrate and washings are evaporated at reduced pressure below 25° to give white crystalline 2-chlorothiirane 1,1-dioxide, m.p. 49–51° (Note 7); yield 10.0–10.5 g.. (80–84%). The product may be further purified by recrystallization from ether-hexane at −70°; m.p. 53–54° (8.9 g. after two recrystallizations) (Note 8) and (Note 9).
s-Trithiane obtained from Eastman Organic Chemicals
was used without further purification.
The gas inlet tube must be sufficiently long to allow the chlorine
to enter near the bottom of the flask, and sufficiently coarse to prevent the pores from becoming clogged by the suspended s-trithiane
. A 6-mm. glass tube with a slightly constricted orifice
has been found to be equally satisfactory.
The rate of addition of chlorine
appears to be important. With rates adequate to maintain the temperature between 40° and 50°, addition times of 1–2 hours are required.
This separation is most conveniently achieved by first decanting as much water as possible from the 4-l. Erlenmeyer flask
. The remaining mixture is then placed in a 4-l. separatory funnel
, and the lower layer is collected. The separatory funnel is then used in the ensuing extractions.
The yield is based on the assumption that 3 molecules of chloromethanesulfonyl chloride
arise from each molecule of s-trithiane
. The checkers obtained a yellow product which had to be redistilled to provide material with the reported refractive index.
The ethereal diazomethane
is prepared by the method of Arndt.4
The checkers employed undistilled material as described in (Note 3)
of the preparation cited.
Use of undistilled diazomethane
solution gives a less pure product, m.p. 38–42°
, which can be recrystallized as described.
The characteristic infrared maxima of 2-chlorothiirane 1,1-dioxide
(Nujol) occur at 3.24, 7.53, and 8.56 μ. Its n.m.r. spectrum (CDCl3
) shows a doublet of doublets at δ 3.17 (J
= 9.5 and 5.5 Hz), a triplet at δ 3.75 (J
= 9.5 Hz), and a doublet of doublets at δ 4.85 (J
= 9.5 and 5.5 Hz).
A characteristic property of thiirane 1,1-dioxides is the ease with which such molecules fragment into sulfur dioxide
and the related olefin on standing for several hours at room temperature. The title compound is no exception; however, the rate of decomposition may be reduced substantially by storage under an inert atmosphere in a freezing compartment (ca.
−5°). Under such conditions the product may be kept for many months.
2-Halothiirane 1,1-dioxides are known to be intermediates in the Ramberg-Bäcklund rearrangement of α,α-dihalo sulfones.5,6,7,8
These three-membered cyclic sulfones are not isolable from such reactions, however, because they are not stable under the conditions of the rearrangement and they undergo further transformations. The present procedure represents the only means presently available for the preparation of halogen-substituted thiirane dioxides.5,6,9
The addition of halosulfenes to diazoalkanes is a convenient and general synthesis which may be extended to the preparation of a variety of thiirane 1,1-dioxides with relative ease.10
Chemical Abstracts Nomenclature (Collective Index Number);
acetic acid (64-19-7)
sulfur dioxide (7446-09-5)
Triethylamine hydrochloride (554-68-7)
methylene chloride (75-09-2)
magnesium sulfate (7487-88-9)
Thiirane, 2-chloro-, 1,1-dioxide (10038-13-8)
chloromethanesulfonyl chloride (3518-65-8)
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